Histone acetylation in drug addiction.

paper Cited Public

Authors: Renthal, William; Nestler, Eric J
Year: 2009
Journal: Seminars in cell & developmental biology
PMID: 19560043
DOI: 10.1016/j.semcdb.2009.01.005
PMCID: PMC2704458

#	Section	Preview
20	Drug-Induced Changes in Histone Acetylation — Genome-wide analysis of histone acetylation in the NAc	Analyzing changes in histone acetylation at specific gene promoters via quantitative ChIP (qChIP)…
21	Drug-Induced Changes in Histone Acetylation — Genome-wide analysis of histone acetylation in the NAc	ChIP-chip analysis of histone acetylation in the NAc of cocaine-treated mice has provided new…
22	Drug-Induced Changes in Histone Acetylation — Genome-wide analysis of histone acetylation in the NAc	cocaine [53]. Genome-wide ChIP-chip analysis reveals that while there are more H3 acetylated genes…
23	Drug-Induced Changes in Histone Acetylation — Genome-wide analysis of histone acetylation in the NAc	Another important result from these first genome-wide studies of histone acetylation in cocaine…
24	Role of HATs and HDACs in drug abuse — Histone acetyltransferases	As discussed above, HATs are enzymes which catalyze the addition of acetyl groups onto histone…
25	Role of HATs and HDACs in drug abuse — Histone acetyltransferases	striatum typically enhance behavioral responses to cocaine [70, 71]. However, since CBP-deficient…
26	Role of HATs and HDACs in drug abuse — Histone deacetylases	Small molecule inhibitors of HDACs have been used in many systems since they were first identified…
27	Role of HATs and HDACs in drug abuse — Histone deacetylases	cocaine, amphetamine, and D1 agonists [53, 54, 76, 77]. Conversely, overexpression of the Class II…
28	Role of HATs and HDACs in drug abuse — Histone deacetylases	In the NAc, endogenous HDAC5 also plays a key role in regulating gene expression in response to…
29	Role of HATs and HDACs in drug abuse — Histone deacetylases	The Class I HDAC, HDAC1 is also involved in the cellular responses to chronic psychostimulant…
30	Functions of histone acetylation in vivo	These studies in drug abuse, together with findings in models of leaning and memory, depression, and…
31	Functions of histone acetylation in vivo	Despite the substantial progress in identifying the genes at which drugs of abuse alter histone…
32	Functions of histone acetylation in vivo	for nearly a week of drug withdrawal [61]. This is an example where histone acetylation on a gene…
33	Future studies and challenges	While drug-induced alterations in histone acetylation have to date been implicated in the behavioral…
34	Future studies and challenges	The study of gene expression and chromatin remodeling in adult brain is made difficult by two major…
35	Future studies and challenges	cellular responses to cocaine. The end result of studying tissue lysates from such a heterogeneous…
36	Future studies and challenges	The second major challenge is determining causality from correlation. How does one determine whether…
37	Conclusions	Histone acetylation has been shown to be involved in modulating the saliency of many environmental…

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Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder.	Dempster EL et al.	—	2011	→
Histone deacetylase inhibition decreases preference without affecting aversion for nicotine.	Pastor V et al.	—	2011	→
Repeated social defeat selectively increases δFosB expression and histone H3 acetylation in the infralimbic medial prefrontal cortex.	Hinwood M et al.	—	2011	→
Repeated toluene exposure modifies the acetylation pattern of histones H3 and H4 in the rat brain.	Sánchez-Serrano SL et al.	—	2011	→
Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain.	Uchida H et al.	—	2010	→
Genetic research: who is at risk for alcoholism.	Foroud T et al.	—	2010	→
HDAC9 links epigenetics to dendrite development (commentary on Sugo et al.).	Harkany T	—	2010	→
Synergistic interactions between histone deacetylase inhibitors and drugs of abuse.	Adachi M et al.	—	2009	→