striatum typically enhance behavioral responses to cocaine [70, 71]. However, since CBP-deficient mice have reduced CBP levels in all brain regions throughout development, it will be important to determine which specific regions in the adult brain are important for CBP’s behavioral effects. Moreover, these studies may also provide insight into what role CREB plays in mediating the downstream functions of CBP in cocaine responses. Mice expressing mutant forms of CREB that cannot interact with CBP [72] may also help address this question.
