There were a total of 29 SNPs in 15 genes in EAs, 9 SNPs in 9 genes in AAs and 22 SNPs in 16 genes in meta-analysis that were marginally to significantly (p<10-5) associated with alcohol and nicotine co-dependence (data available on request). The p values for the 10 top-ranked SNPs in EAs, AAs, and meta-analysis, respectively, are listed in Supplementary Table S3, and the p values in meta-analysis for the 10 top-ranked replicable SNPs are listed in Supplementary Table S4. After correction, 4 SNPs in EAs including rs7445832, rs4700575 and rs2169520 in IPO11-HTR1A region (7.0×10-9≤p≤3.0×10-7 and 6.3×10-4≤FDR≤0.031) and rs17427389 in PLEKHG1 (p=4.3×10-7 and FDR=0.019), rs4610908 in FAM47B in AAs (p=3.2×10-7 and FDR=0.032), and 2 SNPs in meta-analysis including rs9636470 in PLGLB2 (p=3.1×10-8 and FDR=0.003) and rs1318937 in SH3BP5 (p=4.1×10-7 and FDR=0.041) remained significant (p<5×10-7 together with FDR<0.05). Among these significant SNPs, only rs9636470 in PLGLB2 (p=2.4×10-6 in EAs and 0.004 in AAs) and rs1318937 in SH3BP5 (p=2.5×10-5 in EAs and 0.005 in AAs) were replicable between two populations. However, rs9636470 in PLGLB2 was the only replicable significant SNP in
