Extensive genetic overlap was also observed in the presence of weak rg. For example, schizophrenia and ADHD also shared large numbers of ‘causal’ variants (5.4K, sd=0.4K), with only 0.1K unique ADHD variants, despite possessing the weakest rg (0.19, sd=0.010) and rgs (0.26, sd=0.02). This pattern of extensive genetic overlap but weak rg is indicative of mixed effect directions, supported by the MiXeR-estimated proportion of shared ‘causal’ variants with concordant effects (0.58, sd=0.006).
