This is the first study to demonstrate an interaction between ADH1B-rs1229984 and childhood adversity, a stressful environmental risk factor, which each show robust main effects on alcohol phenotypes (Maxdrinks and AUD severity). In an Israeli household sample, we observed that childhood adversity moderated the ADH1B-rs1229984 effect on alcohol use and problems, in that there was a stronger effect of the ADH1B-rs1229984 on heavy alcohol consumption and AUD severity among those who had experienced childhood adversity.
