Childhood adversity and ADH1B-rs1229984 showed a significant additive interaction effect on AUD severity (p-value<0.05). Among participants who experienced childhood adversity, the adjusted mean difference in AUD severity between those with the GG genotype and those with the AA/AG genotype was 0.92. Among participants who did not experience childhood adversity, the adjusted mean difference in AUD severity by genotype was only 0.17. The interaction contrast [IC] (difference in differences) was 0.75 (Table 2, Figure 1b).
