where ncsp,c is a vector of normalized connectivity scores for perturbagen p, relative to query q, across all cell lines in which p was profiled, and Qhi and Qlo are upper and lower quantiles respectively. This procedure compares the Qhi and Qlo quantiles of ncsp,c and retains whichever is of higher absolute magnitude. Thus, maximum quantile is more sensitive to signal in a subset of the cell lines than measures of central tendency such as mean or median. In the analyses presented here, we used Qhi = 67, Qlo = 33
