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Chunk #114 — Quantification and Statistical Analysis — Summarization Across Cell Lines

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A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
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When examining query results, it is often convenient to obtain a perturbagen-centric measure of connectivity that summarizes the results observed in individual cell types. This can be particularly helpful when searching for connections that persist across cell lines or when one is unsure which cell line to examine. Given a vector of normalized connectivity scores for perturbagen p, relative to query q, across all cell lines in which p was profiled, a cell-summarized connectivity score is obtained using a maximum quantile statistic: