Disordered cortical connectivity is now considered a central feature of SCZ, with evidence from human and animal studies demonstrating structural and functional dysconnectivity between several brain regions6–8. Neural functional connectivity measured using EEG has the advantage of temporal resolution on the order of milliseconds, the scale at which most relevant sensory, motor and cognitive phenomena occur8. EEG coherence measures functional connectivity by the degree of synchrony in oscillatory activity between two brain regions, with increased coherence indicating functional integration between these brain regions and decreased coherence reflecting less correlated neural activity9,10. Stated another way, EEG coherence reflects communication between distinct brain regions, which facilitate cognition and behavior11–14. Either extreme of this spectrum may indicate disturbances in neural interactions underlying cognition, particularly in the absence of task-related activity (e.g., Default Mode Network15,16). Differences in resting-state EEG coherence have been observed in individuals with SCZ and in their relatives5, with studies most consistently showing increases in intrahemispheric and interhemispheric coherence in the theta (3–7 Hz), alpha (7–12 Hz) frequencies5, among mixed evidence of mis-connectivity among affected individuals7,17,18. We note that differences in
