individuals with SCZ and in their relatives5, with studies most consistently showing increases in intrahemispheric and interhemispheric coherence in the theta (3–7 Hz), alpha (7–12 Hz) frequencies5, among mixed evidence of mis-connectivity among affected individuals7,17,18. We note that differences in other frequency bands, including the gamma frequency (28–50 Hz) have been reported for spectral power and other aspects of EEG. These inconsistent results may result from small and heterogenous samples, since neural connectivity changes dynamically across the lifespan19, with relatively random network structures in childhood changing to more ordered networks in adolescence and emerging adulthood20. For these reasons, coherence has been particularly useful in the study of normal brain development and neuropsychiatric traits17,21, and in genomic studies of neurodevelopment and mental health conditions22. However, few studies have focused on neurodevelopmental trajectories among adolescents and young adults, some of whom may be prior to their onset of SCZ, but the vast majority of whom will remain unaffected. Such study designs allow a prospective view of future illness but are also relatively uncontaminated by neurobiological sequelae of the illness or its treatment.
