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Chunk #18 — Results — Shared Genetic Architecture Between Psychotic Disorders and Cannabis Phenotypes

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The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study.
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The number of genes mapped to shared loci (i.e., shared genes) ranged widely from 110 mapped to loci shared by SCZ and LCU to no genes mapped to loci shared by BIP and CUD (Supplementary Table 8). The shared genes between SCZ and cannabis phenotypes were enriched for mitochondrial, neuron projection cellular components (Supplementary Table 9), and targets of alcohol, nicotine, and pharmaceutical drugs for treating dementia, AIDS, and rheumatoid arthritis (Supplementary Tables 10–11). The shared genes for BIP and LCU exhibited enrichment for olfactory ensheathing glia cells (Supplementary Table 9), and the drug duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI) (Supplementary Table 12).