The work of Justras-Aswad et al. and Schneider described in this special issue, should propel further investigations aimed at understanding to what extent perturbation of the endocannabinoid system by exposure to exogenous cannabinoids alters developmental processes relevant to schizophrenia. Furthermore, understanding the mechanisms by which exposure to endocannabinoids disrupt neurodevelopmental processes relevant to schizophrenia is also critical. For example, one potential mechanism by which cannabinoids may alter neurodevelopmental processes is by their known effects on neurotrophins.
