neighborhood physical disorder. In an effort to model the genetic architecture of smoking behaviors in African Americans, the first aim of this study is to use the genetic variants associated (P-value <5 × 10−7) with number of cigarettes smoked per day from the STOMP meta-analysis to predict this phenotype in the Detroit Neighborhood Health Study (DNHS), a majority African American population-based sample of individuals living in Detroit. The second aim of this study is to test for interaction between the aggregate measure of molecular genetic risk for cigarette smoking and three environmental exposures: traumatic life events, neighborhood social cohesion and neighborhood physical disorder.
