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Chunk #16 — I. The genetic epidemiology of FTO — FTO and obesity risk over the life course

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The bigger picture of FTO: the first GWAS-identified obesity gene.
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While SNPs in FTO do not influence birth weight88-92, longitudinal studies have shown that they affect body weight already during early childhood, as early as age 3yrs, after which FTO’s effect increases to reach its largest impact at around young adulthood, followed by a subsequent weakening of the effect throughout adulthood.86-90,93,94.