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Chunk #17 — I. The genetic epidemiology of FTO — The role of lifestyle factors in the association between FTO and obesity-susceptibility

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The bigger picture of FTO: the first GWAS-identified obesity gene.
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To gain insight in the potential mechanisms through which variation in FTO leads to increased risk of obesity, many studies examined whether FTO SNPs associate with food intake and physical activity as the two major mediators of body weight regulation.