To test the association between rs2023239 and CB1 receptor levels, CB1 binding was quantified in postmortem human PFC and the relationship between rs2023239 and CB1 binding was assessed. Ten samples were genotyped as TT and 10 as CT. The ANOVA revealed that individuals with the CT genotype for rs2023239 demonstrated significantly greater CB1 binding in Brodmann areas 9 and 10 compared with individuals with the TT genotype (F1,16 = 9.62, P < .01) (Figure 2).
