Because CNR1 receptors modulate the mesocorticolimbic neurocircuitry that underlies drug-seeking behavior in animals,5,6 it was expected that the genetic variation that alters CB1 receptor levels would also be associated with the differential activation of these structures during exposure to alcohol cues. To explore the functional significance of rs2023239, data from a recent neuroimaging study35 were reanalyzed. Participants were 34 heavy drinkers who were right-handed and had no history of psychiatric or neurologic disorders. Two participants had the CC genotype and 8 had the CT genotype. Individuals with at least 1 copy of C (n=10; mean [SD] age, 21.5 [0.71] years; 7 men; all white participants) were age matched with 24 participants who had the TT genotype (mean [SD] age, 22.5 [1.59] years; 17 men; 21 white, 1 Asian, and 2 Latin American participants).
