The CT group demonstrated greater activation when alcohol was contrasted with inactive (ie, rest) and active (ie, litchi juice) appetitive controls in the NAcc, VMPFC, VTA, and OFC compared with the TT group (P < .05) (Figure 3). Pearson product moment correlations between peak activity in these regions and subjective measures indicated several significant findings. In the CT group, the alcohol use disorder score, measured using the AUDIT, was significantly correlated with activation of the NAcc (r = 0.83, P = .003) and the VMPFC (r = 0.68, P = .03) using the alcohol vs active control contrast. In addition, the urge to consume alcohol in the CT group, as measured using the total AUQ score, was also significantly correlated with the VMPFC (r = 0.67, P = .03), the left OFC (r = 0.80, P = .005), and the right OFC (r = 0.62, P = .06). The only correlations that were significant in the TT group were the correlations between the left and right OFC and the AUDIT score (r = 0.42, P < .05 and r = 0.51, P = .01) (Table).
