Neighborhood controls were divided into those who were dependent on either alcohol or a non-opioid illicit drug (N=256) and those who were not (N=275), consistent with the inclusion criteria for non-dependent control group. The ORs for association of rs2236857 and rs2236855 (identical due to complete LD) with heroin dependence in respective comparisons of cases to neighborhood controls, with and without substance dependence diagnoses, were 1.21 (p=0.08) and 1.00 (p=0.98).
