The results of additional analyses comparing cases and neighborhood controls found no association for an OPRD1 SNP that reached even nominal significance; the ORs for rs2236857 and rs2236855 were 1.09 (p>0.28). For a relatively small number of OPRM1 and OPRK1 SNPs, associations of nominal significance were found (Supplementary Table 3); however, none was within an order of magnitude of the p value threshold required to correct for multiple testing.
