Association analyses comparing cases to non-dependent controls for SNPs in the other opioid receptors are most noteworthy for the dearth of findings reaching even nominal significance. Of the 93 OPRM1 SNPs, only rs10485058 attained this minimal standard [p=0.045; OR=0.86 (95%CI 0.74–1.00)]. Nominal significance was found for only 2 of the 22 OPRK1 SNPs: rs12548098 [p=0.016; OR=0.85 (95%CI 0.74–0.97)] and rs7826614 [p=0.015; OR=0.84 (95%CI 0.74–0.97)].
