Lastly, Tan et al. (2013) (65) reported that women with polycystic ovary syndrome had lower levels of CTRP3 than control subjects. Polycystic ovary syndrome is an endocrine system disorder associated with obesity, diabetes, dyslipidemia, and cardiovascular complications and Metformin is a common medication used in the treatment of insulin resistance, obesity and type 2 diabetes. CTRP3 levelswere restored with Metformin treatment along with a general improvement in insulin sensitivity.
