Chunk #67 — II. Samples for genome studies of human addiction vulnerabilities and related phenotypes (Figure 2)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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Genotyping provided data from 70,987 autosomal SNPs using Affymetrix 100K arrays. Allele frequencies for SNPs that displayed a) minor allele frequencies ≥ 0.10, b) genotype success ≥ 0.80, and c) Hardy-Weinberg equilibrium p ≥ 0.001 were used. A generalized estimating equation provided corrections for familial relatedness and other covariates [8].