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Chunk #68 — II. Samples for genome studies of human addiction vulnerabilities and related phenotypes (Figure 2)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.
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L. Sample 12) European American smokers who successfully vs unsuccessfully quit smoking in trials in Philadelphia, Washington DC and Buffalo, New York responded to advertising and physician referrals for help in quitting smoking [118, 119]. Subjects aged 18 – 65 enrolled in a randomized clinical trials for smoking cessation accompanied by standardized behavioral counseling that utilized a blinded, placebo controlled trial of bupropion 300 mg/d or matching placebo × 10 weeks or an open label trial of nicotine nasal spray versus nicotine patch × 8 weeks [118]. 126 individuals with biochemically-confirmed abstinence for at least the 7 days prior to both 8 week and 24 week assessments were contrasted with 140 unsuccessful quitters who were not abstinent at either time point.