In the frequency interval 0.01 to 0.05 Hz, we next examined small world metric values of four anatomical regions of interest in the two groups. These four regions included the left hippocampus, the right hippocampus, the left precentral gyrus, and the right precentral gyrus. These were chosen because we hypothesized significant differences in the hippocampus (a region targeted early in AD), but not in the precentral gyrus (which is typically spared even in the advanced stages of AD) [51]. This regional profiling analysis was performed on the clustering coefficient (and not the path length) because only the former differed significantly between the AD and control groups.
