al. (2004) have shown that P3 amplitude in nonalcoholic adolescent twin pairs who become discordant for AUD as adults also present reduced P3 amplitude, supporting the notion that this risk is familial. Further, Perlman, Johnson, and Iacono (2009) have showed that low P3 amplitude indexes risk for AUD, independent of any deleterious effect of alcohol use. However, despite extensive evidence linking FH of AUD to low P3 amplitude, it is unclear which measures (e.g., dichotomous or density) of FH are more predictive of this significant biomarker of risk for AUD. 3) Variability in P3 across gender and race/ethnicity. The relationship between low P3 amplitude and the heritability of AUD may be subject to modulation by population differences, and gender (Ehlers et al., 2003; Euser et al., 2011). Therefore, these points attest the importance of testing the associations of different FH measures with P3 amplitude and variations in these associations across gender and race/ethnicity.
