We examined whether functional connectivity or GMV of the DMN correlates with episodic memory measures in patients with mTLE, using a different version of PLS. This version examines the relationship between a behavioural measure, in our case episodic memory scores, and brain data as a function of the experimental group (Krishnan et al., 2011). The general difference to the previous PLS version is that, here, the covariance matrix used for SVD stems from correlation values between the behavioural measure (i.e., episodic memory capacity) and all other entries in the brain data matrix (i.e., rather than brain data matrices per group). For our GMV-VM/VSM and FC-VM/VSM-PLS, brain data matrices consisted again of either 20 GMV values or 190 FC values per patient, respectively. GMV and FC matrixes were correlated with behavioural measures, including verbal memory (VM), visuospatial memory (VSM) and IQ scores. To capture a greater variability of episodic memory performance, we concatenated across patients with left and right mTLE. Again, we used 500 permutations to assess significance of the LV and 100 bootstrap samples to assess reliable patterns. We considered
