Data were analysed using R (http://www.r-project.org). Microarray data were processed using bioconductor packages (http://www.bioconductor.org) as described in GEO entry GSE38083. Genes with a q value of <0.001 were considered differentially expressed between genotypes. Gene Ontology (GO) Biological Process enrichment was evaluated using conditional hypergeometric tests (GOstats package). For non-microarray data, differential effects were analysed by analysis of variance followed by Student's t-tests with a pooled variance estimate. A p value <0.05 was considered significant.
