Our rate of adults and adolescents living with a diagnosis of HIV infection among PWID in Puerto Rico (14%) is higher than that published by Perez and colleagues (2.8% [CI 0.6%–12.4%]) [22]. The estimate of the population proportion of PWID in Puerto Rico (1.5%), based on a single household survey, could be an under-estimate. In addition, the investigators cautioned that the small number of HIV-infected persons limited their ability to make reliable prevalence estimates stratified by injection drug use [22].