Our findings provide strong support for association in the chromosome 4 ADH region, for ADH1B*rs1229984, as has been reported multiple times previously (here with p=4.9×10−47), spanning a lengthy chromosomal region (Figure 2a). A different signal at the same locus, rs2066702 (2.29×10−12; Figure 2b), was the only GWS result in AFR. We also report three additional regions in EUR, with prior varying, but never GWS, support: a region on chromosome 17 including CRHR1*rs77804065 (p=1.5×10−12; Figure 2c); chromosome 8, lead SNP rs7821592 (3.6×10−8), closest to XPO7; and at chromosome 10, lead SNP rs1577857 (4.2×10−08), LOC105378478, which has unknown function. The trans-population meta-analysis added two additional novel GWS regions, FGF14 (p=9.86×10−09) and LOC105376602 (p=4.63×10−08)(19).
