We report here findings from a GWAS of maximum habitual alcohol use from the US MVP sample, in EUR and AFR. In EUR, we observed 7.8% SNP-based heritability that is consistent with other large-GWAS of alcohol-related traits which also range from 5% to 10% (14). These SNP-based heritability estimates account for about 15–25% of the heritability reported by twin studies (40). The phenotype tested (i.e., “In a typical month, what is/was the largest number of drinks of alcohol (beer, wine, and/or liquor) you may have had in one day?”) has genetic overlap with both alcohol consumption (UK Biobank: “Amount of alcohol drunk on a typical drinking day” and “Frequency of consuming six or more units of alcohol”) and with alcohol misuse (PGC: DSM-IV Alcohol Dependence; UK Biobank: “Ever been injured or injured someone else through drinking alcohol” and “Ever had known person concerned about, or recommend reduction of, alcohol consumption”).
