After applying a FDR 5% correction for the variants, genes, and tissues tested, we observed 212 significant eQTLs out of 2,855 tests conducted with respect to the GWS loci observed in the trans-ancestry meta-analysis. Considering the top CNS tissue for each eQTL surviving multiple testing correction (Table 3), we observed 37 significant results. Thirty-four relate to rs61667602 (chromosome 17), associated with the expression of multiple genes, where the strongest significance was mostly observed in the cerebellum transcriptomic profile (22/34). Additionally, we identified significant eQTLs with respect to rs1360983 on chromosome 13 (FGF14-AS2, top CNS tissue: spinal cord) and rs2291317 on chromosome 8 (BIN3, top CNS tissue: nucleus accumbens; FAM160B2, top CNS tissue: substantia nigra). Consistent with the strong linkage disequilibrium with the loci identified in the trans-ancestry analysis, similar eQTL results were observed with respect to the variants identified in the EUR analysis.
