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Chunk #10 — Results — Replication Results

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Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.
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in the solute carrier family 35 member G1 (SLC35G1 [Ensembl ENSG00000176273]) (from 1.31 × 10−7 to 1.33 × 10−9). The signal in PI4K2B also improved (P = 5.57 × 10−8 for the full meta-analysis). However, rs186825689 near S100B was no longer GWS (P = 8.27 × 10−8) in the full meta-analysis. The Figure shows Manhattan plots for the regions encompassing RP11-206M11.7 (Figure, A), SLC35G1 (Figure, B), CSMD1 (Figure, C), and PI4K2B (Figure, D) in the discovery sample and after meta-analysis with the replication samples.