The SNPs in Table 2 were tested for CAD association in the 2 replication samples (ICGHD and Yale-Penn 3). Table 3 shows the replication cohort-specific results for these SNPs, with the meta-analysis results from the discovery phase and the discovery + replication phase. The smallest P value in the ICGHD cohort among the 13 SNPs that could be reliably imputed and analyzed (this cohort was European Australian) was at rs74823926 (P = .064) in an intergenic region on chromosome 1. Several associations, however, were replicated in the Yale-Penn 3 sample (Table 3). The P values for 2 of the 3 GWS SNPs improved after meta-analysis with the replication cohorts (rs143244591 in RP11-206M11.7, from 1.38 × 10−8 to 4.32 × 10−10; rs77378271 in CSMD1, from 2.84 × 10−8 to 2.13 × 10−8), as did the P value for another SNP, rs146091982 in the solute carrier family 35 member G1 (SLC35G1 [Ensembl ENSG00000176273]) (from 1.31 × 10−7 to 1.33 × 10−9). The signal in PI4K2B also improved (P = 5.57 × 10−8 for the full meta-analysis). However, rs186825689 near S100B was no
