× 10−8 for the African American meta-analysis) is located 12.4 kb upstream from the gene encoding S100 calcium binding protein (S100B) with contributions from both informative African American samples. Second, rs143244591 (P = 2.18 × 10−8 for the African American meta-analysis) maps to a novel antisense transcript RP11-206M11.7 (Havana gene: OTTHUMG00000159583) located in the gene of the same name on chromosome 3 with at least nominally significant evidence in each of the 3 African American samples. Third, rs77378271(P = 2.76 × 10−8 for the European American meta-analysis) is an intronic SNP in the CUB and Sushi multiple domains 1 gene (CSMD1 [OMIM 608397]) with evidence of association in 3 of the 6 samples. We also identified consistent, non-GWS evidence of association in the combined sample of European American and African American participants with a large block of SNPs in and around the phosphatidylinositol 4-kinase type 2β gene (PI4K2B [OMIM 612101]), with consistent effect direction in every European American and African American population tested (minimum P = 1.74 × 10−7 for the meta-analysis). This signal was GWS when individuals without cannabis exposure were excluded (minimum P = 2.98 × 10−8 for the meta-analysis).
