Manhattan and QQ plots for the meta-analysis discovery GWAS results for African American and European American Yale-Penn 1 and 2 and SAGE cohorts are displayed in eFigures 2 and 3 in the Supplement. We found little evidence of P value inflation. Table 2 shows associations in the discovery sample with P < 1.0 × 10−5 in African American or European American participants or the combined meta-analysis, trimmed for linkage disequilibrium. eTable 1 in the Supplement shows the same results, together with additional information about each SNP, including the results within each discovery sample subgroup, after excluding individuals with no cannabis exposure, and after adjusting for comorbid substance use disorders. We identified GWS associations with reliably imputed SNPs in 3 distinct regions (Table 2), 2 specific to African American participants and 1 in the combined sample. First, rs186825689 (P = 1.86 × 10−8 for the African American meta-analysis) is located 12.4 kb upstream from the gene encoding S100 calcium binding protein (S100B) with contributions from both informative African American samples. Second, rs143244591 (P = 2.18 × 10−8 for the African American
