FASTSNP differs from the above systems in many respects. First, it uses a complete decision tree to assign risk rankings for SNP prioritization. It also considers some novel functional effects not considered by previous works, including the abolition of a protein domain due to exon skipping and the stability of a protein's structure. Another key feature of FASTSNP is that it applies web wrapper agents to query external sources at query time. As a result, it is highly extendable. Moreover, it always provides prioritization based on the most up-to-date information, thereby allowing users to update their queries. A recently published system called Galaxy (32) also aims at accomplishing this task. Their system provides up-to-date information by providing interactive communication to external websites to answer user queries.
