Chunk #45 — Experimental Procedures — Data Analysis

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Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities.

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Peak finding and downstream data analysis was performed using HOMER, a software suite for ChIP-Seq analysis, which in part was created to support this study. Peaks were defined at a 0.1% estimated false discovery rate, indicated as a dashed line in genome browser images.