Chunk #19 — METHODS — Statistical Analyses

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CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.

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To evaluate the robustness of the findings, we analyzed the association between rs1451240 and several smoking phenotypes (cpd and FTCD, coded as a continuous variable in linear regression, dichotomous variable in logistic regression, and ordinal variable in ordered logistic regression). In addition, we modified the inclusion criteria to include only individuals who smoked regularly to determine whether this changed the results.