Chunk #20 — METHODS — Statistical Analyses

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CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.

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We performed a meta-analysis of the independent subset of this study using Metal (26–27). The primary sample we used was the 2,590 subjects that were not included in the previous GWAS of nicotine dependence(5). These results were combined with the published odds ratio and corresponding statistics from the association study in 1,610 subjects from Saccone et al.(28).