Three sets of postmortem brain tissues from the frontal cortex and one set of lymphoblastoid cells were tested in this study: (a) tissue derived from 49 unrelated African Americans was obtained from the National Institute of Child Health and Human Development (NICHD) brain and tissue bank for developmental disorders at the University of Maryland (http://medschool.umaryland.edu/btbank/); (b) tissue derived from 66 unrelated European Australians (35 alcoholics and 31 controls) was received from the Australian Brain Donor Programs NSW Tissue Resource Centre (http://sydney.edu.au/medicine/pathology/trc); (c) tissue derived from 45 unrelated, non-demented elderly European Americans was obtained from the Knight Alzheimer's Disease Research Center at Washington University (http://alzheimer.wustl.edu/); (d) cDNA and gDNA from 120 lymphoblastoid cell lines were obtained from the Rutgers University Cell and DNA Repository (http://www.rucdr.org/). These lymphoblastoid cell lines were generated from 60 unrelated African Americans and 60 unrelated European Americans, who were selected from the COGA dataset based on the genotypes of rs3841324 from our previous study [20]. In the African American subset, 24 subjects are homozygous for the major allele of rs3841324, 21 subjects are homozygous for the minor
