Chunk #22 — 3. Pharmacogenetic Studies of Treatment for Alcohol Use Disorder in Individuals of Diverse Ancestries — 3.2 Individuals of East Asian Ancestry
confounders, the ALDH2 and ADH1B alcohol metabolizing genes were examined as covariates in this study, but neither of these genes had any relationship with the behavioral economic measures. Thus, while in the IV alcohol administration study, NTX was effective at reducing craving in G allele carriers, findings from the behavioral economics study indicate that NTX may not be particularly effective at reducing demand for alcohol in the absence of consumption cost in individuals carrying the G risk allele. More research is needed to understand the underlying mechanisms contributing to these mixed findings.
