Chunk #23 — 3. Pharmacogenetic Studies of Treatment for Alcohol Use Disorder in Individuals of Diverse Ancestries — 3.2 Individuals of East Asian Ancestry
Sex has been controlled for in some of the studies described above,47 but it is important to consider that sex may also moderate the observed pharmacotherapeutic effects. A study examining the frequency of A and G alleles in AD Koreans and healthy controls indicated that the G allele was more frequent in AD women but not in AD men.48 These findings suggest that the benefits of NTX treatment for Asp40 carriers may be limited to female G allele carriers. Thus, enrolling female participants in clinical trials and laboratory studies is an important step of understanding the benefits of NTX for G allele carriers of East Asian ancestry.
