the other findings, such that it was no longer significant (Supplementary Table 8). Significant main effects for sex were observed for PTSD and all substance dependence diagnoses, such that female participants were more likely to be diagnosed with PTSD (B = 0.228, p < 0.001, adjusted-p < 0.001) and less likely to be diagnosed with alcohol (B = −0.178, p < 0.001, adjusted-p < 0.001), cannabis (B = −0.203, p < 0.001, adjusted-p < 0.001), cocaine (B = −0.094, p < 0.001, adjusted-p < 0.001), or opioid (B = −0.090, p < 0.01, adjusted-p < 0.05) dependence, compared to male participants (Supplemental Table 7; Fig. 1). The significant associations between the PGC-PTSD PRS and PTSD, alcohol dependence and cocaine dependence, but not cannabis dependence, remained significant after adjusting p-values for multiple testing using the Benjamini–Hochberg procedure, as did the significant main effects observed for sex. No significant interaction effects of sex on the associations between the PGC-PTSD PRS and PTSD and substance dependence diagnoses were observed (Supplementary Table 7; Fig. 1). Interaction effects of alcohol dependence were observed, such that individuals with a lifetime alcohol dependence diagnosis and higher polygenic risk for PTSD were more likely to have PTSD (B
