In the COGA sub-sample used for the PGC-PTSD PRS analyses, 7.3% of the sample met criteria for PTSD (Supplementary Table 2). The highest prevalent substance dependence diagnosis was alcohol dependence (32.7%), followed by cannabis dependence (20.4%), cocaine dependence (10.2%), and opioid dependence (5.9%). The PGC-PTSD PRS [9] was associated with increased risk for DSM-IV diagnoses of PTSD (B = 0.121, p < 0.01, adjusted-p < 0.01; R2change = 0.013), as well as DSM-IV alcohol- (B = 0.107, p < 0.001, adjusted-p < 0.001; R2change = 0.011) cannabis- (B = 0.063, p < 0.05, adjusted-p > 0.05; R2change = 0.003) and cocaine- (B = 0.079, p < 0.01, adjusted-p < 0.05; R2change = 0.006) dependence, but not with opioid dependence (Supplementary Table 7; Fig. 1). Addition of the problematic alcohol use PRS changed the significance for the cocaine finding, but not the other findings, such that it was no longer significant (Supplementary Table 8). Significant main effects for sex were observed for PTSD and all substance dependence diagnoses, such that female participants were more likely to be diagnosed with PTSD (B
