Recent GWASs have also identified genomic markers associated with suicide attempts (SA) broadly [18, 19] and among individuals with psychiatric illness [20, 21]. The Suicide Working Group of the Psychiatric Genomics Consortium, or PGC (formerly the International Suicide Genetics Consortium) recently identified 12 loci in a large scale meta-analysis of 43,871 individual who had a lifetime suicide attempt and 915,025 controls. Importantly, in prior analyses, the top loci SNP on chromosome 7 remained significant after conditioning on GWAS results for depression [20]. Other GWASs have identified genomewide significant variants for SA within those with other psychiatric disorders: rs45593736 was associated with suicide attempt in major depressive disorder, chr4_23273116_D was associated with SA in bipolar disorder, and rs138689899 was associated in the meta-analysis of suicide attempt in mood disorders (bipolar disorder + major depressive disorder). Levey et al [21] found one genome-wide significant signal near LDHB (rs1677091) in individuals of European ancestries and three associations among individuals of African ancestries, including: rs683813 (ARNTL2), rs72740082 (FAH), and rs11876255. Variants within LDHB and FAH replicated in an independent sample. However, despite the higher rates of suicide attempts, no prior GWAS has examined suicide attempt in the presence of AUD.
