The symptom “nervous, tense, restless or irritable” during cannabis withdrawal also demonstrated evidence for linkage on chromosome 9 between 167 and 177 cM with a peak at 174 cM (LOD = 3.6). Additionally, suggestive evidence for linkage for this withdrawal phenotype was found on chromosome 3 between 89 and 102 cM with a peak at 96 cM (LOD = 2.5) and on chromosome 7 between 65 and 90 cM with a peak at 71cM (LOD = 2.2) (see Table 2 for complete results). Nominal p-values generated by simulation analyses are presented for all three cannabis phenotypes in table 3.
