Chunk #99 — Quantification and Statistical Analysis — Level 3 - Normalization (NORM)

Source: A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
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Normalization yields the expression values of the 978 landmark genes. To obtain expression values for all the remaining genes in the transcriptome, we assume that an unmeasured gene x can be predicted from the measured landmark genes li via linear regression: