Bridging Integrator 1 (BIN1; chromosome 2) is a tumor suppressor gene that can be involved with protein for vesicle trafficking. Mutations in BIN1 may be associated with autosomal recessive centronuclear myopathy. Caenorhabditis elegans experiments have suggested that BIN1 protein might have a role in trafficking APP, ApoE proteins, and Abeta through the endolysosomal pathways, thus BIN1 mutations may be a putative risk factor for LOAD.162
