Chunk #16 — Late-onset Alzheimer’s disease
Text
A poly-T repeat (rs10524523) was identified in exon 6 of the translocase of outer mitochondrial membrane 40 homolog (TOMM40; chromosome 19) gene that can be associated with an earlier age of onset of LOAD in patients with APOE E3/E3 and E3/E4 alleles. Cruchaga et al suggested that TOMM40 and other mitochondrial enzymes might be involved in the onset of LOAD.161